Research Article

[Retracted] Muscone Inhibits the Excessive Inflammatory Response in Myocardial Infarction by Targeting TREM-1

Figure 1

Inflammation and apoptosis are increased during myocardial ischemia-reperfusion injury and the TREM-1 expression was upregulated after myocardial infarction. (a). HE staining confirms the successful modeling of myocardial ischemia. (b). qRT-PCR detects the mRNA expression of IL-1β in the myocardial tissue of the sham group and MI model. (c). qRT-PCR detects the mRNA expression of IL-6 in the myocardial tissue of the sham group and MI model. (d). qRT-PCR detects the mRNA expression of TNFαin the myocardial tissue of the sham group and MI model. (e). qRT-PCR detects the mRNA expression of Bax in the myocardial tissue of the sham group and MI model. (f). qRT-PCR detection of the Bcl-2 mRNA expression in the myocardial tissue of the sham group and MI model. (g). qRT-PCR detection of the TREM-1 mRNA expression in the myocardial tissue of the sham group and MI model. The TREM-1 expression is upregulated during myocardial ischemia. (h). ELISA was used to detect the content of HMGB1 in rat heart tissue homogenate after myocardial infarction model group or sham operation. (I) ELISA was used to detect the production of HSP60 in rat heart tissue homogenate after myocardial infarction model group or sham operation. (J) Western blot was used to detect the production of HMGB1 and HSP60 in rat heart tissue homogenate after myocardial infarction model group or sham operation. .
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