The Pharmacological Mechanism of Xiyanping Injection for the Treatment of Novel Coronavirus Pneumonia (COVID-19): Based on Network Pharmacology Strategy

Table 2

The top 20 genes for the degree value.

PDB ID	Target gene	Degree	UniProt ID	Protein name
6CCY	AKT1	75	P31749	RAC-alpha serine/threonine-protein kinase
4KVP	TP53	65	P04637	Cellular tumor antigen p53
4TWT	TNF	64	P01375	Tumor necrosis factor
4ZS7	IL6	62	P05231	Interleukin-6
6CKZ	CASP3	61	P42574	Caspase-3
6D3O	VEGFA	59	P15692	Vascular endothelial growth factor A
6QHD	STAT3	58	P40763	Signal transducer and activator of transcription 3
6MFA	JUN	57	P05412	Transcription factor AP-1
5J6Z	FN1	55	P02751	Fibronectin
2OW1	MMP9	54	P14780	Matrix metalloproteinase-9
6GES	MAPK3	51	P27361	Mitogen-activated protein kinase 3
4H6J	HIF1A	51	Q16665	Hypoxia-inducible factor 1-alpha
2O72	CDH1	49	P12830	Cadherin-1
2VV1	PPARG	49	P37231	Peroxisome proliferator-activated receptor gamma
4U93	HSP90AA1	47	P07900	Heat shock protein HSP 90-alpha
3IFD	CCL2	46	P13500	C-C motif chemokine 2
5D14	CXCL8	46	P10145	Interleukin-8
1CK7	MMP2	44	P08253	72 kDa type IV collagenase
7P8W	CAT	43	P04040	Catalase
1FOS	FOS	41	P01100	FOS G0S7