Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson’s Disease

Table 2

Acute toxic effect of rotenone in rats (0–14 day).

Group	Date of onset	No. of rats		Severe Parkinson-like symptoms	Cause of death
		Onset	Death
VEH	None	0	0	Symptomless	None
ROT + Sal	3 day, 5 day, 7 day	3	1	Bradykinesia, rigidity, postural instability	Severe weight loss, indigestion, lost the ability to drinking or feeding, iliac passion
ROT + L	None	0	0	Symptomless	None
ROT + H	7day	1	1	Bradykinesia, rigidity, postural instability	Severe weight loss, indigestion, lost the ability to drinking or feeding, iliac passion
ROT + Madopar®	7 day, 11 day	3	1	Bradykinesia, rigidity, postural instability	Severe weight loss, indigestion, lost the ability to drinking or feeding, iliac passion
ROT + L + Madopar®	None	0	0	Symptomless	None

Note. Date of onset: the time of Parkinson-like symptoms began to appear after rotenone injection.