The Chinese Herbal Formula Huoxiang Zhengqi Dropping Pills Prevents Acute Intestinal Injury Induced by Heatstroke by Increasing the Expression of Claudin-3 in Rats

Table 1

The 93 potential target genes of Huoxiang Zhengqi Dropping Pills prevented heatstroke.

No.	Target	Symbol	Entry	No.	Target	Symbol	Entry
1	Thrombin	F2	P00734	48	Progesterone receptor	PGR	P06401
2	Nitric oxide synthase, endothelial	NOS3	P29474	49	Alpha-1A adrenergic receptor	ADRA1A	P35348
3	Sodium channel protein type 5 subunit alpha	SCN5A	Q14524	50	Calcium-activated potassium channel subunit alpha-1	KCNMA1	Q12791
4	Interleukin-6	IL-6	P05231	51	Transcription factor p65	RELA	Q04206
5	Matrix metalloproteinase-9	MMP9	P14780	52	Dipeptidyl peptidase IV	DPP4	P27487
6	Cellular tumor antigen p53	TP53	P04637	53	Leukotriene A-4 hydrolase	LTA4H	P09960
7	RAC-alpha serine/threonine-protein kinase	AKT1	P31749	54	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform	PIK3CG	P48736
8	Caspase-3	CASP3	P42574	55	Alpha-1B adrenergic receptor	ADRA1B	P35368
9	Tumor necrosis factor	TNF	P01375	56	Acetylcholinesterase	ACHE	P22303
10	Estrogen receptor	ESR1	P03372	57	Alpha-2A adrenergic receptor	ADRA2A	P08913
11	Peroxisome proliferator-activated receptor gamma	PPARG	P37231	58	Potassium voltage-gated channel subfamily H member 2	KCNH2	Q12809
12	Coagulation factor VII	F7	P08709	59	Insulin-like growth factor II	IGF2	P01344
13	Beta-2 adrenergic receptor	ADRB2	P07550	60	Serine/threonine-protein kinase Chk1	CHEK1	O14757
14	Interleukin-8	CXCL8	P10145	61	Egl nine homolog 1	EGLN1	Q9GZT9
15	Serum paraoxonase/arylesterase 1	PON1	P27169	62	Sodium-dependent dopamine transporter	SLC6A3	Q01959
16	Mitogen-activated protein kinase 14	MAPK14	Q16539	63	Urokinase-type plasminogen activator	PLAU	P00749
17	Mitogen-activated protein kinase 8	MAPK8	P45983	64	Sodium-dependent noradrenaline transporter	SLC6A2	P23975
18	Coagulation factor Xa	F10	P00742	65	Aryl hydrocarbon receptor	AHR	P35869
19	Caspase-9	CASP9	P55211	66	Alpha-1D adrenergic receptor	ADRA1D	P25100
20	Prostaglandin G/H synthase 2	PTGS2	P35354	67	5-Hydroxytryptamine receptor 3A	HTR3A	P46098
21	Cyclic AMP-responsive element-binding protein 1	CREB1	P16220	68	Scavenger receptor cysteine-rich type 1 protein M130	CD163	Q86VB7
22	C-C motif chemokine 2	CCL2	P13500	69	Amine oxidase [flavin-containing] B	MAOB	P27338
23	Transforming growth factor beta-1	TGFB1	P01137	70	Neuronal acetylcholine receptor protein, alpha-7 chain	CHRNA7	P36544
24	Sodium-dependent serotonin transporter	SLC6A4	P31645	71	5-Hydroxytryptamine 2C receptor	HTR2C	P28335
25	Nitric oxide synthase, inducible	NOS2	P35228	72	Amine oxidase [flavin-containing] A	MAOA	P21397
26	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	73	Alpha-2C adrenergic receptor	ADRA2C	P18825
27	Caspase-8	CASP8	Q14790	74	Protein kinase C delta type	PRKCD	Q05655
28	Interstitial collagenase	MMP1	P03956	75	Cyclin-A2	CCNA2	P20248
29	Myeloperoxidase	MPO	P05164	76	Cytosolic phospholipase A2	PLA2G4A	P47712
30	Microtubule-associated protein 2	MAP2	P11137	77	Cell division protein kinase 2	CDK2	P24941
31	Androgen receptor	AR	P10275	78	NADPH oxidase 5	NOX5	Q96PH1
32	G1/S-specific cyclin-D1	CCND1	P24385	79	G2/mitotic-specific cyclin-B1	CCNB1	P14635
33	Apoptosis regulator Bcl-2	BCL2	P10415	80	Glutamate receptor 2	GRIA2	P42262
34	CGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	Q14432	81	mRNA of protein-tyrosine phosphatase, nonreceptor type 1	PTPN1	P18031
35	Beta-1 adrenergic receptor	ADRB1	P08588	82	Apolipoprotein D	APOD	P05090
36	Metalloproteinase inhibitor 1	TIMP1	P01033	83	Retinoic acid receptor RXR-alpha	RXRA	P19793
37	Transcription factor AP-1	JUN	P05412	84	Fatty acid-binding protein 5	FABP5	Q01469
38	Prostaglandin G/H synthase 1	PTGS1	P23219	85	Muscarinic acetylcholine receptor M3	CHRM3	P20309
39	Proto-oncogene c-Fos	FOS	P01100	86	Prostaglandin E2 receptor EP3 subtype	PTGER3	P43115
40	Fibronectin	FN1	P02751	87	Telomerase protein component 1	TEP1	Q99973
41	Mineralocorticoid receptor	NR3C2	P08235	88	Carbonic anhydrase II	CA2	P00918
42	Apoptosis regulator BAX	BAX	Q07812	89	Muscarinic acetylcholine receptor M2	CHRM2	P08172
43	Glycogen synthase kinase-3 beta	GSK3B	P49841	90	Delta-type opioid receptor	OPRD1	P41143
44	5-Hydroxytryptamine 2A receptor	HTR2A	P28223	91	Lysozyme	LYZ	P61626
45	Mu-type opioid receptor	OPRM1	P35372	92	Ephrin type-B receptor 2	EPHB2	P29323
46	Purine nucleoside phosphorylase	PNP	P00491	93	Bcl-2-binding component 3	BBC3	Q96PG8
47	Protein kinase C alpha type	PRKCA	P17252