Network Pharmacology-Based Analysis of the Potential Biological Mechanisms of Coix Seed against Colorectal Cancer

Table 1

Properties of the active compounds in coix seed and potential mechanisms.

ID	Compound	OB (%)	DL	Reported mechanisms
MOL000449	Stigmasterol	43.83	0.76	Blocking the proliferation of tumor cells [18–20]
MOL001323	Sitosterol-alpha1	43.28	0.78	Inhibition of fungal growth [21]
MOL001494	Mandenol	42	0.19	Lowering cholesterol [22]
MOL000953	Cholesterol (CLR)	37.87	0.68	A raw material for the synthesis of bile acids, vitamin D, and steroid hormones [23, 24]
MOL000359	Sitosterol	36.91	0.75	Interfering with multiple signaling pathways, including cell cycle and apoptosis [25]
MOL008121	2-Monoolein	34.23	0.29	Inhibits Staphylococcus aureus [26]
MOL002882	[(2R)-2,3-dihydroxypropyl] (Z)-octadec-9-enoate	34.13	0.3	—
MOL002372	(6Z,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene	33.55	0.42	—
MOL008118	Coixenolide	32.4	0.43	Upregulates the expression of regulatory T cells in mice [27]