Salvianolic Acid B Suppresses Non-Small-Cell Lung Cancer Metastasis through PKM2-Independent Metabolic Reprogramming

Figure 3

Sal B weakens metabolic reprogramming of NSCLC cells. (a–d) Glucose uptake, lactate production, enolase activity, as well as cellular ATP production of 200 μM Sal B-treated NCI-H2030 and NCI-H1650 cells. (e, f) Measurement of OCR of 200 μM Sal B-treated two NSCLC cells when exposure to oligomycin, FCCP, and Rot/antiA. (g, h) Quantification of basal and maximal OCR of 200 μM Sal B-treated two NSCLC cells. (i, j) Measurement of ECAR of 200 μM Sal B-treated two NSCLC cells after exposing to glucose, oligomycin, and 2-DG. (k, l) Quantification of glycolysis ECAR of above two NSCLC cells. ; ; ; .

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