Research Article

Qiliqiangxin Capsule Modulates Calcium Transients and Calcium Sparks in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Figure 2

The effects of QLQX on spontaneous Ca2+ transients in hiPSC-CMs. (a) Representative Ca2+ transients before and after the QLQX application (83 μg/ml, 3 minutes). (b) The QLQX treatment significantly decreased the frequency but increased the amplitude, rise time, and full duration at half maximum (FDHM) of spontaneous Ca2+ transients. n = 48–50 cells, . (c) In long-QT hiPSC-CMs, QLQX attenuated abnormal Ca2+ transients. n = 11 cells, .
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