Qiliqiangxin Capsule Modulates Calcium Transients and Calcium Sparks in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Figure 6

QLQX treatment (83 μg/ml, 3 minutes) did not change the nucleoplasmic reticulum (NR) structure in hiPSC-CMs (a). n = 18–25 cells. Nuclear Ca²⁺ waves had delayed kinetics compared to that of cytosolic Ca²⁺ waves (b), which was not altered by the QLQX pretreatment in hiPSC-CMs (c). n = 15–20 cells. 10 mM external Ca²⁺ was used to promote Ca²⁺ waves.

(a)

(b)

(c)