Antibiofilm Activity of Azadirachta indica and Catharanthus roseus and Their Synergistic Effects in Combination with Antimicrobial Agents against Fluconazole-Resistant Candida albicans Strains and MRSA

Table 2

Synergistic effect of A. indica and C. roseus on fluconazole and voriconazole against resistant C. albicans strains.

Test sample	Fluconazole	Interpretation	Voriconazole	Interpretation
	FIC index		FIC index
A. indica
CA1	0.13	Synergy	16.13	Antagonism
CA2	5.00	Antagonism	1.5	No difference
CA3	1.00	Additive	1.00	Additive
CA4	0.13	Synergy	0.63	Partial synergy
C. roseus
CA1	5.25	Antagonism	37.00	Antagonism
CA2	1.00	Additive	1.00	Additive
CA3	2.07	No difference	2.17	No difference
CA4	0.63	Partial synergy	0.63	Partial synergy