Antibiofilm Activity of Azadirachta indica and Catharanthus roseus and Their Synergistic Effects in Combination with Antimicrobial Agents against Fluconazole-Resistant Candida albicans Strains and MRSA

Table 7

IC₅₀ values of biofilm inhibition by ethanolic extracts of A. indica and C. roseus against fluconazole-resistant C. albicans strains and MRSA (NCTC12493).

A. indica		C. roseus
Test organisms	IC50 values (mg/mL)	Test organisms	IC50 values (mg/mL)
CA1	8.87 ± 0.10	CA1	1.64 ± 0.01
CA2	2.39 ± 0.02	CA2	3.81 ± 0.06
CA3	1.69 ± 0.01	CA3	1.50 ± 0.01
CA4	1.57 ± 0.01	CA4	1.29 ± 0.01
MRSA (NCTC12493)	1.002 ± 0.001	MRSA	1.73 ± 0.002
Control	—	Control	—

Each value is the average of three independent experiments ± SDs. CA1: Candida albicans 1, CA2: Candida albicans 2, CA3: Candida albicans 3, CA4: Candida albicans 4, MIC: minimum inhibitory concentration, and “—” no activity.