Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade

Figure 5

Effect of GXP on PI3K/Akt pathway on the expression of related proteins. GXP inhibited the activation of ET-1 to PI3K/AKT signaling pathway. The protein expression levels of PI3K, Akt, pAkt, IκB-α, Bax/Bcl-2, and iNOS were determined by Western blotting. The graphs represent the relative activity of these proteins for three independent experiments. (a) The band and molecular weight of each protein in Western blotting; (b) the relative expression of each protein in the physiological group; (c) the relative expression of each protein in the pathological group. In the physiological group, other groups were compared with the control group, and in the pathological group, other groups were compared with the model group (ET-1 group),, compared with the model group (ET-1 group).

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