Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade

Figure 7

The activation of PI3K gives rise to the Akt phosphorylation, pAkt activates the transformation and decomposition of IP, which breaks down the binding with NF-κB, appears as the lower expression of IκB-α, and NF-κB is more activated and transferred into the nucleus, and increases the expression of IL-6, IL-1β, and iNOS and upregulation of Bax/Bcl-2 ratio. Eventually, ET-1 promotes the proliferation and migration of MOVAS. Mice were given GXP tablets (2.43 g/kg·bid for 3 days) 1 h after intragastric administration on the 4th day, and under ether inhalation anesthesia, blood was taken from the abdominal aorta to obtain medicated serum. GXP may inhibit the proliferation and migration of MOVAS by inhibiting the overactivated PI3K/Akt/NF-κB pathway.