Inhibition of Aldose Reductase by Novel Phytocompounds: A Heuristic Approach to Treating Diabetic Retinopathy

Table 3

Ligand binding free energies recorded for the protein-ligand complexes after IFD of the identified compounds with AKR super family of proteins.

Compound	IFD Glide score (kcal/mol)
	ALR2	AKR1B10	ALR1
Epalrestat	−9.147	−7.242	−8.516
Eupalitin-3-O-galactoside	−16.266	−7.340	−8.255
Agnuside	−15.302	−11.711	−9.058
Picroside II	−13.000	−10.363	−8.045
7-O-Methylwogonin	−11.968	−10.114	−8.255