Inhibition of Aldose Reductase by Novel Phytocompounds: A Heuristic Approach to Treating Diabetic Retinopathy

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center">ALR2</td><td class="align_center">AKR1B10</td><td class="align_center">ALR1</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Epalrestat</td><td class="align_center">Tyr48, Trp111, Hie110</td><td class="align_center">Tyr49</td><td class="align_center">Trp114, Arg312</td></tr><tr><td class="align_left">Eupalitin-3-O-galactoside</td><td class="align_center">Tyr48, Hie110, Phe122, Val297, Ala299, Ser302</td><td class="align_center">Tyr49</td><td class="align_center">Trp22, Tyr116, Tyr50</td></tr><tr><td class="align_left">Agnuside</td><td class="align_center">Tyr48, Trp219, Ser302</td><td class="align_center">Tyr49</td><td class="align_center">Trp22, Trp220, Trp114, Ala219</td></tr><tr><td class="align_left">Picroside II</td><td class="align_center">Trp20, Lys21, Val47, Trp48, Hie110, Ala299</td><td class="align_center">Tyr49, Trp21, Cso299</td><td class="align_center">Tyr50, Met302, Arg309</td></tr><tr><td class="align_left">7-O-Methylwogonin</td><td class="align_center">Hie110, Leu300, Leu301</td><td class="align_center">Trp21</td><td class="align_center">Trp114, Met302, Phe125</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>IFD interactions of the identified compounds to determine specificity of the compounds towards ALR2 among AKR super family proteins.</div>

Evidence-Based Complementary and Alternative Medicine

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Table 4

Table 4: Inhibition of Aldose Reductase by Novel Phytocompounds: A Heuristic Approach to Treating Diabetic Retinopathy 