Integration of Lipidomics and Transcriptomics Reveals the Efficacy and Mechanism of Qige Decoction on NAFLD

Table 3

Differentially expressed genes (DEGs) involved in insulin resistance and triglycerides biosynthesis pathways.

Gene name	Description	MOD vs CON		QGL vs MOD
		Log2FC	value	Log2FC	value
SIK1	Salt induced kinase 1	−2.039	1.82E-08	1.284	1.23E-07
PPP1R3C	Protein phosphatase 1 regulatory subunit 3C	0.427	0.2704	−2.135	3.51E-07
PPP1R3G	Protein phosphatase 1 regulatory subunit 3G	−2.765	0.003757	1.589	0.0107
CRTC2	CREB-regulated transcription coactivator 2	−0.086	0.627441	−1.519	9.14E-05
PGC-1α	Alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha	−0.283	0.528324	−1.176	0.009018125
G6PC	Glucose-6-phosphatase	0.413	0.129002	−1.771	1.54E-10
SREBP1	Sterol-regulatory element-binding protein 1	0.728	0.227177	−1.427	2.34E-05
GPAT3	Glycerol-3-phosphate acyltransferase 3	1.18	0.203196	−1.878	0.049292787