Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of <i>Tripterygium wilfordii</i> against Pulmonary Artery Hypertension

<table class="table-group" id="tab6"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Chemical composition</td><td class="align_center">Target</td><td class="align_center">Ka (1/M ∗ S)</td><td class="align_center">Kd (1/S)</td><td class="align_center">KD (M)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Kaempferol</td><td class="align_center">CASP3</td><td class="align_center">9.50<i>e</i>2</td><td class="align_center">7.27<i>e</i> − 3</td><td class="align_center">7.65<i>e</i> − 6</td></tr><tr><td class="align_left">Triptolide</td><td class="align_center">PARP1</td><td class="align_center">2.39<i>e</i>2</td><td class="align_center">9.99<i>e</i> − 3</td><td class="align_center">4.18<i>e</i> − 5</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Ka: association constant; Kd: dissociation constant; KD: equilibrium dissociation constant.<br/></div></td></tr></table>

<div>The kinetic affinities between active components and target proteins.</div>

Evidence-Based Complementary and Alternative Medicine

tab6

Table 6

Table 6: Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of <i>Tripterygium wilfordii</i> against Pulmonary Artery Hypertension 

Table 6 | Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of Tripterygium wilfordii against Pulmonary Artery Hypertension 