Preclinical Pharmacokinetics, Biodistribution, and Acute Toxicity Evaluation of Caerin 1.9 Peptide in Sprague Dawley Rats

Table 3

Pharmacokinetic parameters of F3 after single and repeated dose administration to rats calculated by WinNonlin software.

Pharmacokinetic parameters	Single dose (1.0 mg/kg)		Repeated dose (10.0 mg/kg)
			1st dose		14th dose
	Male	Female	Male	Female	Male	Female
T1/2 (h)	1.16	0.677	4.58	1.33	0.894	1.03
Tmax (h)	1.00	0.500	1.00	1.00	0.500	1.00
Cmax (ng/mL)	256	110	591	256	527	496
AUC0−last (h × ng/mL)	661	216	1890	740	1270	1102
AUC0−Inf (h × ng/mL)	686	222	1906	751	1274	1110
AUC_%Extrap_obs (%)	3.62	2.88	0.807	1.48	0.365	0.658
MRTInf_obs (h)	2.05	1.42	3.26	2.18	2.06	1.91
Vz_F_obs (mL/kg)	2431.95	4402.21	34647.55	25498.49	10121.99	13419.28
Cl_F_obs (mL/h/kg)	1458.26	4504.48	5247.61	13313.00	7846.61	9011.18
AUClast/D (h × mg/mL)	661	216	189	74	127	110
Cmax ratio of M/F	2.327		2.309		1.063
AUClast ratio of M/F	3.060		2.554		1.152
14th/1st ratio of Cmax	——		Male: 0.892, female: 1.938
14th/1st ratio of AUClast	——		Male: 0.672, female: 1.489