Research Article
Preclinical Pharmacokinetics, Biodistribution, and Acute Toxicity Evaluation of Caerin 1.9 Peptide in Sprague Dawley Rats
Table 4
Hematological values of male rats.
| | Parameters | Single dose | Repeated dose | | Vehicle control | 1.0 mg/kg | 10.0 mg/kg | 100.0 mg/kg | 10.0 mg/kg |
| | RBC (1012/L) | 7.838 ± 0.324 | 8.163 ± 0.679 | 7.916 ± 0.383 | 7.742 ± 0.232 | 6.94 ± 0.18 | | HCT (%) | 47.7 ± 1.72 | 48.4 ± 1.29 | 47.5 ± 1.89 | 47.62 ± 1.59 | 42.18 ± 0.92 | | HGB (g/dL) | 15.08 ± 0.49 | 15.1 ± 0.41 | 14.72 ± 0.59 | 14.6 ± 0.55 | 12.68 ± 0.34 | | MCV (fL) | 60.88 ± 1.65 | 59.58 ± 4.36 | 60.06 ± 2.02 | 61.52 ± 0.65 | 60.78 ± 1.44 | | MCH (pg) | 19.24 ± 0.43 | 18.63 ± 1.63 | 18.6 ± 0.49 | 18.86 ± 0.15 | 18.28 ± 0.56 | | MCHC (g/dL) | 31.62 ± 0.38 | 31.23 ± 0.69 | 30.98 ± 0.24 | 30.66 ± 0.36 | 30.08 ± 0.52 | | ABRETIC (109/L) | 257.42 ± 45.92 | 250.78 ± 19.32 | 252.72 ± 25.77 | 270.82 ± 25.29 | 338.6 ± 20.2 | | WBC (109/L) | 10.148 ± 1.419 | 9.315 ± 0.344 | 12.12 ± 2.998 | 10.654 ± 1.291 | 13.19 ± 3.49 | | ABNEUT (109/L) | 1.412 ± 0.348 | 1.185 ± 0.375 | 1.498 ± 0.573 | 1.742 ± 0.58 | 2.43 ± 1.39 | | ABLYMP (109/L) | 8.378 ± 1.263 | 7.695 ± 0.12 | 10.178 ± 2.676 | 8.444 ± 1.168 | 10.1 ± 2.26 | | ABMONO (109/L) | 0.224 ± 0.083 | 0.283 ± 0.124 | 0.262 ± 0.043 | 0.27 ± 0.06 | 0.34 ± 0.09 | | ABBASO (109/L) | 0.008 ± 0.004 | 0.005 ± 0.006 | 0.012 ± 0.008 | 0.01 ± 0.01 | 0.01 ± 0.01 | | ABEOS (109/L) | 0.07 ± 0.043 | 0.088 ± 0.013 | 0.086 ± 0.059 | 0.11 ± 0.062 | 0.17 ± 0.06 | | PLT (109/L) | 862.8 ± 111.4 | 862.8 ± 95.1 | 878 ± 118.5 | 985.4 ± 65 | 1421.5 ± 225.3 | | MPV (fL) | 9.06 ± 0.19 | 9.35 ± 0.33 | 9.62 ± 0.41 | 9.26 ± 0.24 | 9.05 ± 0.36 | | APTT (seconds) | 17.46 ± 1.32 | 17.44 ± 0.85 | 17.86 ± 1.84 | 17.34 ± 1.96 | 16.2 ± 1.82 | | PT (seconds) | 20.18 ± 1.22 | 19.76 ± 0.92 | 19.88 ± 0.94 | 20.14 ± 0.95 | 20.87 ± 1.2 |
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Values are expressed as mean ± SD.
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