Preclinical Pharmacokinetics, Biodistribution, and Acute Toxicity Evaluation of Caerin 1.9 Peptide in Sprague Dawley Rats

Table 5

Hematological values of female rats.

Parameters	Single dose				Repeated dose
	Vehicle control	1.0 mg/kg	10.0 mg/kg	100.0 mg/kg	10.0 mg/kg
RBC (10^12/L)	7.778 ± 0.219	7.584 ± 0.568	7.954 ± 0.424	8.042 ± 0.561	6.04 ± 0.37
HCT (%)	46.06 ± 0.6	45.34 ± 3.13	46.98 ± 1.22	47.16 ± 1.49	38.2 ± 1.34
HGB (g/dL)	14.92 ± 0.23	14.44 ± 1.06	14.9 ± 0.29	14.96 ± 0.47	11.62 ± 0.50
MCV (fL)	59.26 ± 1.3	59.86 ± 0.56	59.1 ± 1.71	58.8 ± 2.76	63.38 ± 2.38
MCH (pg)	19.2 ± 0.58	19.06 ± 0.27	18.78 ± 0.75	18.64 ± 1	19.25 ± 0.69
MCHC (g/dL)	32.38 ± 0.3	31.82 ± 0.47	31.76 ± 0.46	31.68 ± 0.33	30.4 ± 0.46
ABRETIC (10^9/L)	191.58 ± 55.04	226.5 ± 33.41	192.02 ± 21.07	215.84 ± 21.41	273.87 ± 31.75
WBC (10^9/L)	7.444 ± 1.547	8.022 ± 3.840	7.922 ± 1.865	7.28 ± 2.163	10.67 ± 1.900
ABNEUT (10^9/L)	1.146 ± 0.512	1.71 ± 1.516	1.128 ± 0.308	1.148 ± 0.434	2.53 ± 0.45
ABLYMP (10^9/L)	5.988 ± 1.053	5.956 ± 2.336	6.526 ± 1.92	5.886 ± 1.807	7.64 ± 1.61
ABMONO (10^9/L)	0.18 ± 0.08	0.228 ± 0.234	0.136 ± 0.034	0.142 ± 0.094	0.23 ± 0.08
ABBASO (10^9/L)	0.006 ± 0.005	0.006 ± 0.005	0.01 ± 0.007	0.008 ± 0.004	0.01 ± 0
ABEOS (10^9/L)	0.066 ± 0.011	0.072 ± 0.034	0.072 ± 0.032	0.06 ± 0.031	0.16 ± 0.07
PLT (10^9/L)	979.8 ± 82.6	1081.6 ± 83.2	1004.4 ± 93.7	987 ± 86.1	1357.67 ± 169.65
MPV (fL)	8.92 ± 0.25	9.02 ± 0.30	9.28 ± 0.20	9 ± 0.19	8.58 ± 0.42
APTT (seconds)	16.8 ± 0.65	16.94 ± 1.15	18.24 ± 1.36	17.02 ± 1.47	14.9 ± 0.28
PT (seconds)	20.04 ± 0.91	20.06 ± 0.75	19.44 ± 0.70	19.72 ± 0.50	20.45 ± 1.16

Values are expressed as mean ± SD.