Preclinical Pharmacokinetics, Biodistribution, and Acute Toxicity Evaluation of Caerin 1.9 Peptide in Sprague Dawley Rats

Table 7

Absolute and relative weights of organs of female rats.

Parameters	Single dose				Repeated dose
	Vehicle control	1.0 mg/kg	10.0 mg/kg	100.0 mg/kg	10.0 mg/kg
Body weight (g)	242.98 ± 9.59	238.86 ± 7.94	243.48 ± 10.53	238.86 ± 9.44	233.55 ± 16.03
Brain (g)	2.0674 ± 0.0674	2.0504 ± 0.0552	2.0232 ± 0.044	1.9918 ± 0.0665	1.9517 ± 0.0244
Heart (g)	1.0142 ± 0.104	1.1086 ± 0.1559	0.999 ± 0.0943	1.0914 ± 0.0821	1.1247 ± 0.1287
Liver (g)	7.7002 ± 0.7548	7.7464 ± 0.2893	7.3692 ± 0.709	7.8582 ± 0.5028	7.5278 ± 0.6229
Spleen (g)	0.5588 ± 0.0540	0.57 ± 0.1214	0.5508 ± 0.0854	0.545 ± 0.0571	0.6908 ± 0.0750
Kidneys (g)	1.9894 ± 0.1988	1.9364 ± 0.118	1.8596 ± 0.1438	1.924 ± 0.0685	1.7017 ± 0.123
Adrenals (g)	0.0748 ± 0.0118	0.0728 ± 0.0097	0.0758 ± 0.0114	0.076 ± 0.0116	0.0793 ± 0.0101
Thymus (g)	0.5176 ± 0.0353	0.5216 ± 0.0746	0.535 ± 0.0762	0.478 ± 0.0725	0.427 ± 0.0886
Thyroid (g)	0.0308 ± 0.0039	0.0282 ± 0.0029	0.0338 ± 0.005	0.0344 ± 0.0057	0.0242 ± 0.0053
Uterus (g)	0.5624 ± 0.1174	0.6212 ± 0.0948	0.4664 ± 0.1167	0.5842 ± 0.0922	0.4797 ± 0.1336
Ovaries (g)	0.1002 ± 0.0182	0.1036 ± 0.0242	0.096 ± 0.0182	0.108 ± 0.0223	0.093 ± 0.0151
Organ-to-body weight ratio (%)
Brain	0.8514 ± 0.0271	0.8588 ± 0.0192	0.8318 ± 0.0335	0.8342 ± 0.0162	0.8388 ± 0.0590
Heart	0.4168 ± 0.0364	0.4632 ± 0.0555	0.4104 ± 0.0365	0.4576 ± 0.0363	0.4815 ± 0.0436
Liver	3.1644 ± 0.2149	3.2444 ± 0.1224	3.0258 ± 0.2399	3.29 ± 0.1695	3.2212 ± 0.0775
Spleen	0.2298 ± 0.0182	0.2382 ± 0.0477	0.2252 ± 0.0267	0.2278 ± 0.018	0.2968 ± 0.036
Kidneys	0.8182 ± 0.0641	0.8106 ± 0.0353	0.764 ± 0.0516	0.806 ± 0.029	0.7308 ± 0.0653
Adrenals	0.0308 ± 0.004	0.0304 ± 0.005	0.031 ± 0.0042	0.0316 ± 0.0043	0.034 ± 0.0034
Thymus	0.2134 ± 0.0167	0.2184 ± 0.0331	0.2192 ± 0.0247	0.2012 ± 0.0371	0.1817 ± 0.0285
Thyroid	0.0126 ± 0.0017	0.0118 ± 0.0008	0.0138 ± 0.0016	0.0144 ± 0.0027	0.0105 ± 0.0023
Uterus	0.2308 ± 0.0433	0.2602 ± 0.0375	0.1914 ± 0.0455	0.2442 ± 0.0337	0.2067 ± 0.0629
Ovaries	0.0412 ± 0.0066	0.0432 ± 0.0094	0.0394 ± 0.0067	0.0452 ± 0.0084	0.0397 ± 0.0044
Organ-to-brain weight ratio (g/g)
Heart	49.016 ± 4.291	53.986 ± 6.753	49.414 ± 4.975	54.812 ± 3.894	57.62 ± 6.476
Liver	372.406 ± 34.108	378.002 ± 17.196	364.644 ± 39.044	394.656 ± 24.796	385.71 ± 31.435
Spleen	27.062 ± 2.869	27.816 ± 5.976	27.206 ± 4.067	27.338 ± 2.415	35.388 ± 3.677
Kidneys	96.252 ± 9.422	94.388 ± 3.839	91.964 ± 7.656	96.64 ± 3.443	87.178 ± 6.079
Adrenals	3.62 ± 0.579	3.556 ± 0.528	3.748 ± 0.558	3.814 ± 0.545	4.06 ± 0.477
Thymus	25.066 ± 1.98	25.46 ± 3.812	26.42 ± 3.537	24.094 ± 4.264	21.867 ± 4.445
Thyroid	1.492 ± 0.194	1.374 ± 0.111	1.67 ± 0.243	1.732 ± 0.323	1.238 ± 0.267
Uterus	27.082 ± 4.803	30.302 ± 4.505	23.074 ± 5.887	29.296 ± 4.16	24.592 ± 6.939
Ovaries	4.836 ± 0.799	5.052 ± 1.175	4.75 ± 0.919	5.412 ± 1.018	4.763 ± 0.76

Values are expressed as mean ± SD.