Effects of Hibiscus sabdariffa Calyxes Aqueous Extract on Antioxidant Status and Histopathology in Mammary Tumor-Induced in Rats

Figure 1

Kaplan–Meier curve (a) of the effects of H. sabdariffa extract on the survival of animals and body weight evolution (b) during 21 weeks post-DMBA induction. NOR = Animals serving as normal control and receiving distilled water (vehicle); DMBA = Animals serving as negative control and receiving distilled water (vehicle); TAMOX + DMBA = Animals serving as positive control and receiving tamoxifen at a dose of 3.3 mg/kg; and H. sabdariffa + DMBA = Animals receiving H. sabdariffa calyxes extract at doses of 125, 250, and 500 mg/kg. All animals except those in the normal group (NOR) were given a single dose of DMBA (50 mg/kg; s.c.). # < 0.05, ###  < 0.001 compared to the normal control (NOR) and  < 0.05,  < 0.001 compared to the negative control.

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(b)