Effects of Hibiscus sabdariffa Calyxes Aqueous Extract on Antioxidant Status and Histopathology in Mammary Tumor-Induced in Rats

Figure 2

Effects of H. sabdariffa calyxes extract on tumor morphology (a), volume (b), and CA 15-3 levels (c). NOR = Animals serving as normal control and receiving distilled water (vehicle); DMBA = Animals serving as negative control and receiving distilled water (vehicle); TAMOX + DMBA = Animals serving as positive control and receiving tamoxifen at a dose of 3.3 mg/kg; and H. sabdariffa + DMBA = Animals receiving H. sabdariffa calyxes extract at doses of 125, 250, and 500 mg/kg. All animals except those in the normal group (NOR) were exposed to a single dose of DMBA (50 mg/kg; s.c.). ###  < 0.001 compared to the NOR group and ^∗ < 0.05, ^∗∗ < 0.01 ^∗∗∗ < 0.001 compared to the DMBA group.

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(b)

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