Effects of Hibiscus sabdariffa Calyxes Aqueous Extract on Antioxidant Status and Histopathology in Mammary Tumor-Induced in Rats

Figure 3

Photomicrographs (HE × 400) of cross-section of mammary gland (NOR) or tumors obtained after 21 weeks of treatment with different substances. NOR = Animals serving as normal control and receiving distilled water (vehicle); DMBA = Animals serving as negative control and receiving distilled water (vehicle); TAMOX + DMBA = Animals serving as positive control and receiving tamoxifen at a dose of 3.3 mg/kg; and H. sabdariffa + DMBA = Animals receiving H. sabdariffa calyxes extract at doses of 125, 250, and 500 mg/kg. All animals except those in the normal group (NOR) were exposed to a single dose of DMBA (50 mg/kg; s.c.). La = light of the acini; Ca = acinar cells; At = adipose tissue; Se = eosinophilic secretion, L = lobule; ULH = hypertrophied lobular unit Ne = neoplasia; Ul = ulcerative degradation.