Effects of Hibiscus sabdariffa Calyxes Aqueous Extract on Antioxidant Status and Histopathology in Mammary Tumor-Induced in Rats

Figure 4

Photomicrographs (HE × 400) showing sections of the liver, kidneys, and lungs after 21 weeks of treatment. NOR = Animals serving as normal control and receiving distilled water (vehicle); DMBA = Animals serving as negative control and receiving distilled water (vehicle); TAMOX + DMBA = Animals serving as positive control and receiving tamoxifen at a dose of 3.3 mg/kg; and (H) sabdariffa + DMBA = Animals receiving (H) sabdariffa calyxes extract at doses of 125, 250, and 500 mg/kg. All animals except those in the normal group (NOR) were exposed to a single dose of DMBA (50 mg/kg; s.c.). Vp = portal vein; H = hepatocyte; S = sinusoid; A = alveolus; Sa = alveolar sac; G = glomerulus; Dt = distal tube; Ne = neuron; Co = cortex.