Effects of Hibiscus sabdariffa Calyxes Aqueous Extract on Antioxidant Status and Histopathology in Mammary Tumor-Induced in Rats
Table 5
Effects of H. sabdariffa calyxes extract on some hematological parameters after 21 weeks post-DMBA exposition.
Parameters
NOR
DMBA
TAMOX + DMBA
H. sabdariffa + DMBA
125
250
500
WBC (×103µL−1)
10.60 ± 1.09
21.56 ± 1.96##
12.00 ± 1.91
14.99 ± 2.61
25.14 ± 3.45
12.00 ± 1.78
Lymphocytes (%)
78.04 ± 2.56
43.81 ± 6.55###
70.02 ± 5.26
58.5 ± 6.98
33.24 ± 2.05
68.22 ± 4.70
Monocytes (%)
19.21 ± 2.71
47.14 ± 5.45###
16.12 ± 4.30
8.53 ± 1.78
37.86 ± 6.37
26.81 ± 4.38
Granulocytes (%)
0.86 ± 0.17
0.34 ± 0.04
1.31 ± 0.13
1.5 ± 0.19
0.53 ± 0.16
1.3 ± 0.23
RBC (×103µL−1)
8.16 ± 0.69
5.82 ± 0.50
7.58 ± 0.34
7.85 ± 1.64
3.96 ± 0.77
6.41 ± 0.99
Hematocrite (%)
46.1 ± 3.18
30.75 ± 3.68
38.86 ± 4.19
36.7 ± 3.94
26.26 ± 4.73
36.08 ± 3.71
MCV (fL)
57.41 ± 2.33
59.96 ± 2.610
56.28 ± 0.95
65.41 ± 3.01
68.45 ± 4.18
59.9 ± 1.50
Platelets(×103µL−1)
574.57 ± 34.38
461.8 ± 50.09
614.93 ± 18.46
423.4 ± 122.32
449.33 ± 77.48
479.8 ± 56.15
MCH (pg)
18.62 ± 1.59
16.06 ± 0.58
17.51 ± 0.36
23.61 ± 7.23
16.61 ± 0.48
17.86 ± 1.01
Hemoglobin (g/dL)
14.64 ± 0.71
9.31 ± 1.13##
12.06 ± 1.31
10.68 ± 0.93
5.5 ± 0.96
11.03 ± 1.55
MCHC (g/dL)
32.17 ± 1.25
27.23 ± 1.15##
31.18 ± 0.67
27.18 ± 0.93
24.61 ± 0.92
27.31 ± 1.03
IG (%)
0.12 ± 0.04
0.6 ± 0.23
0.32 ± 0.11
1.03 ± 0.30
0.9 ± 0.27
0.15 ± 0.06
NOR = Animals serving as normal control and receiving distilled water (vehicle); DMBA = Animals serving as negative control and receiving distilled water (vehicle); TAMOX + DMBA = Animals serving as positive control and receiving tamoxifen at a dose of 3.3 mg/kg; and H. sabdariffa + DMBA = Animals receiving H. sabdariffa calyxes extract at doses of 125, 250, and 500 mg/kg. All animals except those in the normal group (NOR) were exposed to a single dose of DMBA (50 mg/kg; s.c.). # < 0.05, ## < 0.01; ### < 0.001 compared to the NOR group; < 0.05, < 0.01, < 0.001 compared to the DMBA group.
