Research Article
Postmarketing Reevaluation of Chinese Traditional Therapy Kangbingdu Oral Liquid in the Treatment of the Common Cold
Table 1
Demographic characteristics and baseline data.
| | Characteristics | Kangbingdu liquid (n = 1986) | Placebo (n = 661) | value |
| | Age, mean (SD) | 36.1 (14.90) | 36.1 (14.81) | 0.7105 |
| Sex
Female
Male | 893 (45.12%)
1086 (54.88%) | 303 (45.84%)
358 (54.16%) | 0.9106 |
| | Race | | | 0.2337 | | Han | 1924 (96.88%) | 631 (95.46%) | | | Others | 62 (3.12%) | 30 (4.54%) | |
| | Marriage | | | 0.7909 | | Yes | 1081 (54.43%) | 361 (54.61%) | | | No | 905 (45.57%) | 300 (45.39%) | |
| | Clinic diagnosis | | | 0.1080 | | Common cold | 1857 (93.50%) | 616 (93.19%) | | | Flu | 129 (6.50%) | 45 (6.81%) | | | Highest body temperature | 37.1 ± 0.73 | 36.9 ± 0.70 | 0.5693 |
| | Fever | | | | | No | 1274 (64.15%) | 418 (63.24%) | | | Yes | 712 (35.85%) | 243 (36.76%) | |
| | Time from cold to visit the doctor | | | 0.9682 | | ≤ 24h | 1283 (64.60%) | 393 (59.46%) | | | > 24h且 ≤ 48h | 703 (35.40%) | 268 (40.54%) | |
| | Influenza exposure in the week prior | | | 0.0639 | | No | 1808 (91.04%) | 593 (89.71%) | | | Yes | 178 (8.96%) | 68 (10.29%) | |
| | Influenza vaccinations | | | 0.5497 | | No | 1698 (85.50%) | 561 (84.87%) | | | Yes | 117 (5.89%) | 42 (6.35%) | | | Total score, mean (SD) | 8.5 (4.59) | 8.4 (4.21) | |
| | Aversion to wind | | | 0.9626 | | None | 1156 (58.21%) | 380 (57.49%) | | | Slightly | 574 (28.90%) | 205 (31.01%) | | | More clearly | 213 (10.73%) | 60 (9.08%) | | | Severe | 43 (2.17%) | 16 (2.42%) | |
| | Aversion to cold | | | 0.9992 | | None | 1074 (54.08%) | 357 (54.01%) | | | Slightly | 602 (30.31%) | 202 (30.56%) | | | More clearly | 261 (13.14%) | 85 (12.86%) | | | Severe | 49 (2.47%) | 17 (2.57%) | |
| | Fever | | | 0.9433 | | None | 1181 (59.47%) | 394 (59.61%) | | | Slightly | 380 (19.13%) | 129 (19.52%) | | | More clearly | 394 (19.84%) | 123 (18.61%) | | | Severe | 31 (1.56%) | 15 (2.27%) | |
| | Cough | | | 0.1526 | | None | 823 (41.44%) | 251 (37.97%) | | | Slightly | 704 (35.45%) | 246 (37.22%) | | | More clearly | 380 (19.13%) | 141 (21.33%) | | | Severe | 79 (3.98%) | 23 (3.48%) | |
| Stuffy nose
None slightly
More clearly
Severe |
668 (33.64%)
728 (36.66%)
520 (26.18%)
70 (3.52%) |
246 (37.22%)
232 (35.10%)
164 (24.81%)
19 (2.87%) | 0.1044 |
| | Runny nose | | | 0.5931 | | None | 594 (29.91%) | 188 (28.44%) | | | Slightly | 718 (36.15%) | 245 (37.07%) | | | More clearly | 571 (28.75%) | 194 (29.35%) | | | Severe | 103 (5.19%) | 34 (5.14%) | |
| | Sore throat | | | 0.5173 | | None | 556 (28.00%) | 186 (28.14%) | | | Slightly | 601 (30.26%) | 215 (32.53%) | | | More clearly | 719 (36.20%) | 222 (33.59%) | | | Severe | 110 (5.54%) | 38 (5.75%) | |
| | Muscle aches | | | 0.4802 | | None | 1076 (54.18%) | 371 (56.13%) | | | Slightly | 570 (28.70%) | 178 (26.93%) | | | More clearly | 303 (15.26%) | 98 (14.83%) | | | Severe | 37 (1.86%) | 14 (2.12%) | |
| | Headache | | | 0.4222 | | None | 957 (48.19%) | 323 (48.87%) | | | Slightly | 631 (31.77%) | 221 (33.43%) | | | More clearly | 356 (17.93%) | 110 (16.64%) | | | Severe | 42 (2.11%) | 7 (1.06%) | |
| | Fatigue | | | 0.5125 | | None | 826 (41.59%) | 267 (40.39%) | | | Slightly | 787 (39.63%) | 263 (39.79%) | | | More clearly | 333 (16.77%) | 117 (17.70%) | | | Severe | 40 (2.01%) | 14 (2.12%) | |
| | Sweat | | | 0.4521 | | None | 1429 (71.95%) | 485 (73.37%) | | | Slightly | 451 (22.71%) | 145 (21.94%) | | | More clearly | 90 (4.53%) | 26 (3.93%) | | | Severe | 16 (0.81%) | 5 (0.76%) | |
| | Total scores mean(95%CI) | 8.50 (8.30 to 8.70) | 8.42 (8.10 to 8.74) | 0.6777 |
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