Network Pharmacology Analysis and Experimental Verification on Antiangiogenesis Mechanism of <i>Hedyotis diffusa</i> Willd in Liver Cancer

<div>Treatment effect of HDW on liver cancer growth and angiogenesis in the orthotopic mouse models. (a) The schedule of orthotopic liver cancer model treatment and imaging. (b) C57BL/6 mice with orthotopic Hepa1-6 tumor burden were treated with HDI intraperitoneally (50, 100, or 150 mg/kg) every other day (<i>n</i> = 6 per group). Representative photographs of liver tumors after the indicated treatments; the blue dotted lines indicate the tumor regions. (c) Body weight curve in vehicle and HDW-treated group. (d) Liver index in vehicle and HDW-treated group. (e) Immunofluorescence staining examination of CD31 and <i>α</i>-SMA in tumor sections from vehicle or HDW-treated group. All panels are of 200x magnification. 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Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Network Pharmacology Analysis and Experimental Verification on Antiangiogenesis Mechanism of <i>Hedyotis diffusa</i> Willd in Liver Cancer 

Evidence-Based Complementary and Alternative Medicine

Network Pharmacology Analysis and Experimental Verification on Antiangiogenesis Mechanism of Hedyotis diffusa Willd in Liver Cancer

Figure 2