Xueliankoufuye Suppresses Microglial Activation with Inflammatory Pain by Blocking NF-κB Signaling Pathway

Figure 1

Analgesic effect of XL on complete Freund’s adjuvant (CFA)‐induced inflammatory joint pain in rats. The analgesic activity evaluation protocol is operated in accordance with (a). (b) The changes of the mechanical withdrawal threshold induced by CFA were detected by electronic Von Frey test. (c) Paw withdrawal threshold was measured by electronic Von Frey test after oral administration of XL, TGWP, and DS at 30 mins, 1 h, 2 h and 4 h. (d) The analgesic effect at different time points after oral administration XL, TGWP, and DS were detected by electronic Von Frey test. Data are expressed as means ± SEM (n = 10 rats in each group). Statistical significance was determined by two-way ANOVA followed by post hoc Tukey analyses where vs. control-ipsilateral paw, ^### vs. control group, , , vs. model group.

(a)

(b)

(c)

(d)