Xueliankoufuye Suppresses Microglial Activation with Inflammatory Pain by Blocking NF-κB Signaling Pathway

Figure 3

Effect of XL on carrageenan‐induced inflammatory muscle pain in rats. The analgesic activity evaluation protocol is operated in accordance with (a). (b) After carrageenan injection, the mechanical withdrawal threshold of the ipsilateral paw in the model group was significantly reduced, which was statistically different from that of the control group, while the contralateral mechanical withdrawal threshold was not affected. (c) After oral administration of XL 30 mins, 1 h, 2 h and 4 h mechanical withdrawal threshold was measured by electronic Von Frey test. (d) On the first day, the third day, and the fifth day after carrageenan injection, the mechanical withdrawal threshold of rats one hour after oral administration of XL was measured by electronic Von Frey test. Data are expressed as means ± SEM (n = 10 rats in each group). Statistical significance was determined by two-way ANOVA followed by post hoc Tukey analyses where vs. control-ipsilateral paw, ^### vs. control group, , , vs. model group.

(a)

(b)

(c)

(d)