Vascular Endothelial Growth Factor Single Nucleotide Polymorphism +405 G/C (rs2010963) is associated with Levels, Infection Severity, and Amputation among South Indian Diabetic Foot Ulcer Patients
Table 1
Clinical and biochemical characteristics of the study subjects.
Clinical parameters (n = 754)
Healthy controls (n = 297)
T2DMϮ (n = 242)
DFUϮϮ (n= 215)
Gender (M/F)
150/147
123/119
117/98
Age (years)
51.1 ± 9.9
52.5 ± 11.1
50.8 ± 10.9
BMI (kg/m2)
23.7 ± 1.1
27.1 ± 4.5
27.4 ± 3.7
Systolic BP (mm Hg)
118.7 ± 12.1
129.3 ± 16.5
129.7 ± 18.6
Diastolic BP (mm Hg)
78.1 ± 8.5
87.7 ± 10.1
87.2 ± 9.9
Fasting plasma glucose (mg/dL)
101.8 ± 8.9
165.2 ± 56.4
171.3 ± 59.2
Postprandial plasma glucose (mg/dL)
121.7 ± 19.2
221.7 ± 57.4
234.2 ± 63.8
Glycated hemoglobin (%)
5.5 ± 0.4
9.1 ± 2.0
11.0 ± 2.1
Total serum cholesterol (mg/dL)
151.7 ± 23.9
178.3 ± 32.9
181.4 ± 33.5
Serum triglycerides (mg/dL)
118.5 ± 15.5
163.7 ± 49.1
170.5 ± 44.7
HDL-cholesterol (mg/dL)
42.3 ± 7.8
36.4 ± 8.1
35.5 ± 7.9
LDL-cholesterol (mg/dL)
85.9 ± 5.1
124.4 ± 27.5
132.5 ± 23.8
Urea (mg/dL)
20.5 ± 5.7
22.4 ± 5.1
30.5 ± 7.4
Creatinine (mg/dL)
0.8 ± 0.1
1.1 ± 0.1
1.1 ± 0.3
All data are reported as mean ± SD for continuous variables. BMI-Body mass index; SBP-systolic blood pressure; DBP-diastolic blood pressure; FPG-fasting plasma glucose; PPG-postprandial plasma glucose; HbA1c-glycated hemoglobin; HDL-high-density lipoprotein; LDL-low-density lipoprotein. < 0.05; < 0.01; < 0.001. Ϯindicates comparison was made between T2DM and healthy controls subjects. ϮϮindicates comparison was made between T2DM and DFU subjects.
