Vascular Endothelial Growth Factor Single Nucleotide Polymorphism +405 G/C (rs2010963) is associated with Levels, Infection Severity, and Amputation among South Indian Diabetic Foot Ulcer Patients

Table 3

Distribution of genotype and allele frequencies of VEGF +405G/C SNP based on the severity of ulcer grades.

Genotype/allele	DFU (n = 215)				Chi-square test/fisher’s exact test value
	Uninfected/grade-I (n = 84)	Mild infection/grade-II (n = 60)	Moderate infection/grade-III (n = 45)	Severe infection/grade-IV (n = 26)
GG	65 (77.38%)	40 (66.67%)	26 (57.78%)	9 (34.62%)	<0.0001
GC	17 (20.24%)	13 (21.67%)	9 (20.0%)	4 (15.38%)
CC	2 (2.38%)	7 (11.67%)	10 (22.22%)	13 (50.00%)
G	147 (87.50%)	93 (77.50%)	61 (67.78%)	22 (42.31%)	<0.0001
C	21 (12.50%)	27 (22.50%)	29 (32.22%)	30 (57.69%)