Vascular Endothelial Growth Factor Single Nucleotide Polymorphism +405 G/C (rs2010963) is associated with Levels, Infection Severity, and Amputation among South Indian Diabetic Foot Ulcer Patients

Table 4

Genetic association of VEGF +405G/C (rs2010963) gene SNP in DFU subjects: odds ratio (OR) for minor alleles and their homozygous and heterozygous genotypes.

SNP (n = 745)	Healthy controls vs. T2DM		Healthy controls vs. DFU		T2DM vs. DFU
	Unadjusted OR (95% CI)	Adjusted OR (95% CI)^a	Unadjusted OR (95% CI)	Adjusted OR (95% CI)^a	Unadjusted OR (95% CI)	Adjusted OR (95% CI)^a
GG	Ref		Ref		Ref
GC	0.96 (0.62–1.48), 0.87	0.84 (0.21–1.1), 0.79	1.03 (0.66–1.60), 0.89	0.89 (0.27–1.1), 0.82	1.06 (0.67–1.69), 0.78	0.7 (0.4–1.2), 0.001
CC	2.72 (1.21–6.14), 0.01	2.24 (1.14–5.27), 0.001	5.59 (2.61–11.9), 0.0001	6.02 (2.45–8.38), 0.0001	2.05 (1.12–3.74), 0.018	2.22 (1.09–3.51), 0.001
OR for minor “C” allele	1.43 (1.02–2.0), 0.03		2.25 (1.63–3.12), 0.0001		1.57 (1.14–2.17), 0.005

^aOdds ratio (OR) adjusted for confounding factors (age, gender, and BMI). The figures in bold were significant.  < 0.01;  < 0.001.