Hypokinetic Activity of Menthofuran on the Gastrointestinal Tract in Rodents

Table 1

Effect of the oral treatment of mice with menthofuran 25 mg/kg (MFur-25), 50 mg/kg (MFur-50), and 100 mg/kg (MFur-100) or loperamide 6 mg/kg (Lop-6) on the elimination of watery stools on diarrheal activity of castor oil model.

Treatment	n	Dose	Diarrheal faeces	Diarrheal
			(n/4 h; mean ± S.E.M.)	Inhibition (%)
Normal	8	—	0.13 ± 0.13	—
Control	8	10 mL/kg	17.31 ± 1.94	0.0
Menthofuran	8	25 mg/kg	15.00 ± 1.04	13.3
	8	50 mg/kg	12.93 ± 1.15	24,1
	8	100 mg/kg	11.36 ± 2.07	34.4
Loperamide	8	6 mg/kg	4.79 ± 0.75	72.3

Data are presented as the mean ± S.E.M. , when compared with the control group (ANOVA and the Newman–Keuls’ test).