Preclinical Trial of Ocotea puberula (Rich.) Nees (“Canela-Guaicá”) in Wound Healing: Validation of a Traditional Medicine Practice Used by Indigenous Groups in Southern Brazil

Table 2

Histological scores of wounds throughout the experiment according to such criteria: inflammatory response, angiogenesis, and neocollagenesis for experimental groups at different time intervals.

Animal group	Inflammatory response after 7 days of injury	Angiogenesis after 14 days of injury	Neocollagenesis after 21 days of injury
	Mean ± SD	Mean ± SD	Mean ± SD
CGBE	2.20 ± 0.33^a	2.40 ± 0.06^a	2.00 ± 0.71^a
Negative control	1.00 ± 0.00^b	1.60 ± 0.33^b	2.40 ± 0.55^a
Positive control	1.00 ± 0.00^b	1.20 ± 0.25^b	2.60 ± 0.55^a

one-way nonparametric ANOVA (Kruskal–Wallis test); different letters on the columns indicate the statistical difference . Note. CGBE, “canela-guaicá” bark extract; SD, standard deviation.