Garlic Extract Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells Via Endoplasmic Reticulum Stress Pathway

<div>The pro-apoptotic effect of Z-Ajoene on NSCLC cell apoptosis is activated by ERS via DLG1/YAP signaling inhibition. (a) Western blot revealed DLG1, LATS2, and YAP protein expressions in A549 and H1299 cells treated with Z-ajoene. (b) The RT-qPCR assay revealed DLG1 and YAP mRNA expressions in A549 and H1299 cells. (c) The difference in cell apoptosis between groups was determined by flow cytometry. (d) Differences in Bip, PERK, ATF4, and CHOP protein expressions between groups were detected using the western blot analysis.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: Garlic Extract Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells Via Endoplasmic Reticulum Stress Pathway 