Evidence-Based Complementary and Alternative Medicine

Research Article

Evaluation on the Efficacy and Safety of Panax Notoginseng Saponins in the Treatment of Stroke among Elderly People: A Systematic Review and Meta-Analysis of 206 Randomized Controlled Trials

Table 2

ROB individual (risk of bias of the included studies).


Publications	ROB items
Publications	Random sequence generation (Selection bias)	Allocation concealment (Selection bias)	Blinding of participants & personnel (Performance bias)	Blinding of outcome assessors (Detection bias)	Incomplete outcome data (Attrition bias)	Selective reporting (reporting bias)	Other bias

Fei Li, 1999	Low	Unclear	Unclear	Unclear	Low	High	Low
Yunjing Jin, 2002	Low	Unclear	Unclear	Unclear	Low	Low	Low
Mingxia Jiang, 2004	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Hua Yang, 2005	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Shuyi Song, 2008	Low	Low	Low	Unclear	Low	Low	Low
Borong Zhou, 2008	Low	Low	Unclear	Unclear	Low	Unclear	Low
Dongmei Chang, 2009	Low	Low	Unclear	Unclear	Low	Unclear	Low
Lijun Jia, 2008	Low	Low	Unclear	Unclear	Low	Unclear	Low
Ying Gao, 2011	Low	Low	Unclear	Unclear	Low	Unclear	Low
Xiangdong Luo, 2011	Low	Low	Unclear	Unclear	Low	Unclear	Low
Zhi Shang, 2011	Low	Low	Unclear	Unclear	Low	Low	Low
Hongfen Chen, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Haiqiu Liang, 2012	Low	Low	Unclear	Unclear	Low	Unclear	Low
Kui Lin, 2012	Low	Low	Unclear	Unclear	Low	Unclear	Low
Qiongfen Wu, 2012	Low	Unclear	Low	Low	Low	Unclear	Low
Guoxiang Hu, 2013	Low	Low	Unclear	Low	Low	Unclear	Low
Yan Han, 2014	Low	Low	Unclear	Unclear	Low	Unclear	Low
Guosheng Zhang, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xiangyong Feng, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yuanlin Li, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Zhiqing Wang, 2015	Low	Unclear	Unclear	Unclear	Low	High	Low
Jing Zhao, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yan Cao, 2016	Low	Unclear	Unclear	Unclear	Low	High	Low
Xulin Ke, 2016	Low	Low	Unclear	Unclear	Low	Unclear	Low
Song Li, 2016	Low	Low	Unclear	Unclear	Low	Unclear	Low
Yuqing Li, 2016	Low	Low	Unclear	Unclear	Low	High	Low
Huiying Liu, 2016	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yan Wen, 2016	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Qiang Yu, 2016	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Chunlin Zhou, 2016	Low	Unclear	Low	Unclear	Low	Unclear	Low
Yaozhong Hu, 2017	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Wei Li, 2017	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Xiaojun Liu, 2017	Low	Unclear	Unclear	Unclear	Low	High	Low
Yang Wang, 2017	Low	Unclear	Unclear	Low	Low	Unclear	Unclear
Junhua Yang, 2017	Low	Low	Unclear	Unclear	Low	Low	Low
Mai Chen, 2018	Low	Low	Unclear	Low	Low	Unclear	Unclear
Zhiqing Gao, 2018	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Fangying Ling, 2018	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Bo Tang, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Xiaoyu Wang, 2018	Low	Low	Unclear	Unclear	Low	High	Low
Zhigang Wu, 2018	Low	Unclear	Unclear	Low	Low	Unclear	Low
Dejun Xia, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Yuming Zhang, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Xiaomin Zhu, 2018	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Chu Gao, 2019	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yafen Guan, 2019	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xianzhong Qi, 2018	Low	Low	Unclear	Low	Low	Unclear	Unclear
Jundong Xia, 2019	Low	Low	Unclear	Low	Low	Unclear	Low
Kun Zhao, 2019	Low	Low	Unclear	Unclear	Low	Unclear	Low
Xuecai Feng, 2020	Low	Unclear	Unclear	Low	Low	Unclear	Low
Yang Liu, 2020	Low	Unclear	Unclear	Low	Low	Unclear	Low
Jinqiang Lu, 2020	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Hao Yu, 2020	Low	Low	Unclear	Unclear	Low	Unclear	Low
Yingwei Zhang, 2020	Low	Low	Unclear	Low	Low	Unclear	Low
Haiyan Du, 2021	Low	Unclear	Low	Unclear	Low	Unclear	Unclear
Li Yao, 2021	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Weiping Zang, 2021	Low	Low	Unclear	Low	Low	Unclear	Low
Xiping Zhang, 2021	Low	Low	Unclear	Unclear	Low	Unclear	Low
Dongyang Gao, 2022	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xiaoqiu Wu, 2001	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Lin Chen, 2002	Low	Unclear	Unclear	Low	Low	Unclear	Low
Leisen Han, 2003	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yuming Tan, 2003	Low	Unclear	Low	Unclear	Low	Unclear	Low
Hui Li, 2004	Low	Unclear	Unclear	Low	Low	Unclear	Low
Wenming Yang, 2004	Low	Unclear	Unclear	Unclear	Low	High	Low
Ning Ao, 2005	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Rui Chen, 2005	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Tiejun Dai, 2005	Low	Unclear	Unclear	Low	Low	Unclear	Unclear
Yanping Guo, 2005	Low	Low	Unclear	Unclear	Low	Unclear	Low
Songlin Chen, 2006	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Qiaolin Ou, 2006	Low	Unclear	Low	Unclear	Low	Unclear	Low
Yongcheng Zhang, 2006	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Guili Gao, 2007	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xinmin Wang, 2007	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xianping Wei, 2007	Low	Unclear	Unclear	Unclear	Low	High	Low
Deliang Yao, 2007	Low	Unclear	Unclear	Low	Low	Unclear	Low
Shuikang Ding, 2008	Low	Low	Unclear	Low	Low	Unclear	Low
Xiaoneng Mo, 2008	Low	Unclear	Unclear	Low	Low	Unclear	Low
Xiaobin Ye, 2008	Low	Unclear	Unclear	Low	Low	Unclear	Low
Xiaoyan Chen, 2009	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Shuikang Ding, 2009	Low	Low	Unclear	Low	Low	Unclear	Low
Hanbiao Gan, 2009	Low	Unclear	Unclear	Unclear	Low	High	Low
Huibing Huang, 2009	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Rong Fan, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yunxie Guo, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Wenlong Li, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Bin Liu, 2010	Low	Unclear	Unclear	Low	Low	Unclear	Low
Shulin Lu, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Junhua Ma, 2010	Low	Unclear	Unclear	Unclear	Low	High	Unclear
Xunwen Wang, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Tao Yang, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Jianjun Yin, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yuqin Zhang, 2010	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Conglian Feng, 2011	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Yi Gao, 2011	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Bixian Liang, 2011	Low	Unclear	Unclear	Unclear	Low	Low	Unclear
Yanli Liu, 2011	Low	Unclear	Unclear	Low	Low	Unclear	Low
Hua Mei, 2011	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Qibo Ran, 2011	Low	Unclear	Low	Unclear	Low	Unclear	Low
Yongsheng Wang, 2011	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xiaoshi Zhang, 2011	Low	Unclear	Unclear	Unclear	Low	High	Low
Guofeng Gao, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Linrong Gao, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Meilin Huang, 2012	Low	Unclear	Low	Low	Low	Unclear	Low
Rongfeng Jiang, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Chunhong Li, 2012	Low	Unclear	Unclear	Low	Low	Unclear	Low
Ruiqi Li, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Qingping Liu, 2012	Low	Unclear	Low	Unclear	Low	Unclear	Low
Ke Su, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Lanzhi Tong, 2012	Low	Unclear	Low	Unclear	Low	Unclear	Low
Fangting Wu, 2012	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Fenguo Zhang, 2012	Low	Unclear	Low	Unclear	Low	High	Unclear
Xiaoshi Zhang, 2012	Low	Unclear	Unclear	Low	Low	Unclear	Low
Yanli Zhao, 2012	Low	Unclear	Unclear	Unclear	Low	High	Unclear
Saihua Zhu, 2012	Low	Unclear	Unclear	Unclear	Low	High	Unclear
Mingxian Chen, 2013	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yuxun Chen, 2013	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yu Deng, 2013	Low	Low	Unclear	Unclear	Low	Unclear	Low
Yongzhong Li, 2013	Low	Unclear	Unclear	Unclear	Low	High	Low
Feifei Wang, 2013	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yu Wu, 2013	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Huilin Xie, 2013	Low	Low	Unclear	Unclear	Low	Unclear	Low
Shanyu Xiong, 2013	Low	Low	Unclear	Unclear	Low	High	Unclear
Xiaoli Yao, 2013	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Haijie Zhang, 2013	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Guiying Che, 2014	Low	Unclear	Unclear	Low	Low	Unclear	Low
Zhengquan Chen, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Dongmei Fang, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Fang Fang, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Zhiyan Gu, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Cunming Li, 2014	Low	Low	Unclear	Unclear	Low	Low	Low
Qin Li, 2014	Low	Low	Unclear	Unclear	Low	Unclear	Low
Hongyan Liu, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
LiQiang Qu, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Fen Wu, 2014	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yang Zhang, 2014	Low	Low	Unclear	Low	Low	Unclear	Low
Xian Zhao, 2014	Low	Low	Unclear	Unclear	Low	Unclear	Low
Qingli Zeng, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Xishan Chen, 2015	Low	Low	Unclear	Unclear	Low	High	Low
Xiaomei Chen, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Bo Jin, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Huijun Li, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Jianwei Lv, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yong Ma, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Zhenxian Shen, 2015	Low	Low	Unclear	Low	Low	Unclear	Low
Dan Sun, 2015	Low	Unclear	Low	Unclear	Low	Unclear	Low
Xia Wang, 2015	Low	Unclear	Unclear	Unclear	Low	High	Unclear
Lijun Wu, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Yanfei Xiang, 2015	Low	Unclear	Unclear	Unclear	Low	High	Unclear
Yinguang Zhang, 2015	Low	Unclear	Unclear	Unclear	Low	High	Low
Li Zheng, 2015	Low	Low	Unclear	Unclear	Low	Unclear	Low
Yudong Zhou, 2015	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Haiping Gu, 2016	Low	Unclear	Unclear	Unclear	Low	High	Low
Yan Jiao, 2016	Low	Low	Unclear	Low	Low	Unclear	Low
Yinchun Leng, 2016	Low	Unclear	Unclear	Unclear	Low	High	Low
Dongzhen Piao, 2016	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Liyuan Qin, 2016	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Xiaohong Wei, 2016	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Shuhua Wu, 2016	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Can Zhao, 2016	Low	Unclear	Unclear	Unclear	Low	High	Low
Jianyong Zheng, 2016	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Zhe Feng, 2017	Low	Unclear	Unclear	Unclear	Low	High	Low
Biao Fu, 2017	Low	Low	Unclear	Unclear	Low	Unclear	Low
Lili Liu, 2017	Low	Unclear	Low	Unclear	Low	Unclear	Low
Xinyou Shu, 2017	Low	Unclear	Low	Unclear	Low	Unclear	Low
Hui Zhang, 2017	Low	Unclear	Unclear	Low	Low	Unclear	Unclear
Sufen Chen, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Low
Desheng Dan, 2018	Low	Unclear	Unclear	Low	Low	Unclear	Low
Aiqin Fan, 2018	Low	Low	Unclear	Unclear	Low	High	Low
Wei Fu, 2018	Low	Low	Unclear	Low	Low	Unclear	Low
Lijuan Han, 2018	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Wubiao Huang, 2018	Low	Unclear	Unclear	Unclear	Low	Low	Low
Yuanjun Li, 2018	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Mengjue Wang, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Low
Tianpeng Wang, 2018	Low	Low	Unclear	Low	Low	Unclear	Unclear
Airong Zeng, 2019	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Chaoqun Gao, 2019	Low	Low	Unclear	Unclear	Low	Unclear	Low
Shizhan Yang, 2019	Low	Unclear	Low	Unclear	Low	Unclear	Low
Huili Liang, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Low
Junjun Liang, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Unclear
Wenlan Tan, 2018	Low	Low	Unclear	Unclear	Low	Unclear	Low
Rong Zou, 2018	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Caihua Chen, 2019	Low	Unclear	Unclear	Low	Low	Unclear	Unclear
Minghui Chen, 2019	Low	Low	Unclear	Low	Low	Unclear	Unclear
Binqing Guo, 2019	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Debo Huang, 2019	Low	Unclear	Unclear	Unclear	Low	High	Low
Baogui Liu, 2019	Low	Low	Unclear	Low	Low	Unclear	Low
Chaofeng Wang, 2019	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Fenghua Wu, 2019	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Xiamixinuer·Aihemaiti, 2020	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Dengfu Yan, 2020	Low	Low	Unclear	Low	Low	Unclear	Low
Hongjun Yang, 2020	Low	Unclear	Unclear	Low	Low	Unclear	Low
Haitao Hu, 2021	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Zhongyin Li, 2021	Low	Low	Unclear	Unclear	Low	Unclear	Low
Qiubo Qiao, 2021	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Lihong Rong, 2021	Low	Unclear	Unclear	Low	Low	Unclear	Low
Haijiao Sun, 2021	Low	Low	Unclear	Low	Low	Unclear	Low
Weihui Qin, 2021	Low	Unclear	Unclear	Unclear	Low	Unclear	Unclear
Feifei Tan, 2021	Low	Unclear	Unclear	Unclear	Low	High	Unclear
Xiaolin Tong, 2021	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Hailin Wang, 2021	Low	Unclear	Unclear	Unclear	Low	Unclear	Low
Shan Wang, 2021	Low	Unclear	Unclear	Low	Low	Unclear	Low
Yanfen Wang, 2021	Low	Unclear	Unclear	Low	Low	Unclear	Low
Chunfang Wu, 2021	Low	Low	Unclear	Unclear	Low	Unclear	Low
Jie Chen, 2022	Low	Low	Unclear	Unclear	Low	High	Low
Wei Gao, 2022	Low	Unclear	Unclear	Unclear	Low	Unclear	Low