Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents

Table 5

Physical data for synthesized compounds.

Code	Compounds	Mol Wt	Mol. Formula	Solubility	m.p (°C)	% Yield	R f value
IIIa	2-{(E)-[(2-hydroxy phenyl) methylidene]amino}-1,3-benzothiazole-6-sulfonamide	333.30	C14H11N3O3S2	CHCl3, CH3OH, C2H5OH, DMSO	92–98	55	0.68
IIIb	2-{(E)-[(3-hydroxyphenyl) methylidene]amino}-1,3-benzothiazole-6-sulfonamide	333.30	C14H11N3O3S2	CHCl3, CH3OH, C2H5OH, DMSO	95–100	43	0.55
IIIc	2-{(E)-[(4-hydroxyphenyl) methylidene]amino}-1,3-benzothiazole-6-sulfonamide	333.30	C14H11N3O3S2	CHCl3, CH3OH, C2H5OH, DMSO	95–100	45	0.51
IIId	2-{(E)-[(2-nitrophenyl) methylidene]amino}-1,3-benzothiazole-6-sulfonamide	294.37	C14H11N4O4S2	CHCl3, CH3OH, C2H5OH, DMSO	105–109	39	0.59
IIIe	2-{(E)-[(3-nitrophenyl) methylidene] amino}-1,3-benzothiazole-6-sulfonamide	294.37	C14H11N4O4S2	CHCl3, CH3OH, C2H5OH, DMSO	101–105	45	0.82
IIIf	2-{(E)-[(4-nitrophenyl)methylidene] amino}-1,3-benzothiazole-6-sulfonamide	294.37	C14H11N4O4S2	CHCl3, CH3OH, C2H5OH, DMSO	95–100	48	0.64
IIIg	2-{(E)-[(2-chlorophenyl)methylidene]amino}-1,3-benzothiazole-6-sulfonamide	294.37	C14H11ClN3O2S2	CHCl3, CH3OH, C2H5OH, DMSO	120–125	39	0.8
IIIh	2-{(E)-[(3-chlorophenyl) methylidene] amino}-1,3-benzothiazole-6-sulfonamide	294.37	C14H11ClN3O2S2	CHCl3, CH3OH, C2H5OH, DMSO	130–135	39	0.62
IIIi	2-{(E)-[(4-chlorophenyl)methylidene] amino}-1,3-benzothiazole-6-sulfonamide	294.37	C14H11ClN3O2S2	CHCl3, CH3OH, C2H5OH, DMSO	125–130	39	0.64