Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents
Table 6
Diuretic activity of IIIb and IIIe derivatives.
Treatment
Dose
Urinary volume (ml)
Urinary excretion (Vo/Vt) X 100
Diuretic action UEt/UEc
Diuretic activity DAt/DAu
Lipschitz value
Control
0.9% NaCl 25 ml/kg
2.2 ± 0.act25
68.75
—
—
—
Urea
1 gm/kg
4.1 ± 0.45
128.12
1.86
—
1.67
Acetazolamide
25 mg/kg
3.56 ± 0.45
114.83
1.67
0.89
0.89
45 mg/kg
4.21 ± 0.45
126.96
1.84
0.98
1.84
IIIb
25 mg/kg
3.7 ± 0.31
112.12
1.63
0.87
0.87
45 mg/kg
4.25 ± 0.21
128.18
1.85
0.99
1.04
IIIe
25 mg/kg
3.81 ± 0.35
119.06
1.73
0.93
0.92
45 mg/kg
4.43 ± 0.26
134.24
1.95
1.04
1.95
UEt = Urinary excretion in the test group; UEc = Urinary excretion in the control group; DAt = Diuretic action in the test group; DAu = Diuretic action of urea. (Dunnett’s multiple comparison test) when using one way ANOVA. ,, (Dunnett’s multiple comparison test) when using one way ANOVA.
