Qinggan Huoxue Recipe Protects against Experimental Alcoholic Liver Fibrosis through CXCL16 Inhibition

Figure 4

QGHXR ameliorates liver fibrosis after ethanol plus CCl₄ administration in mice. C57BL/6J mice were either fed a Lieber–DeCarli liquid diet containing 4% ethanol or pair-fed a control diet, and mice were intraperitoneally injected with CCl₄ (0.1 mL/kg) for 8 weeks. At week 5, mice were administered with 100, 200, and 400 mg/kg QGHXR by gavage daily for 4 weeks. (a) Representative Masson staining, 100x. (b) The fibrotic gene expression in the liver. (c) Hepatic hydroxyproline levels. The values represent means ± SEM (n = 8). , vs. ethanol + CCl₄.

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