Qinggan Huoxue Recipe Protects against Experimental Alcoholic Liver Fibrosis through CXCL16 Inhibition

Figure 8

CXCL16 treatment compromised QGHXR-generated protective effects on liver fibrosis in ethanol-fed mice with CCl₄ injection. C57BL/6J mice were fed a Lieber–DeCarli liquid diet containing 4% ethanol and intraperitoneally injected with CCl₄ (0.1 mL/kg) for 8 weeks. At week 5, mice were administered with 400 mg/kg QGHXR by gavage daily and 0.1 mg/kg CXCL16 (i.v., once per week) for 4 weeks. (a) Representative Masson staining, 100×. (b) The fibrotic gene expression in the liver. (c) Hepatic hydroxyproline levels. The values represent means ± SEM (n = 8). , vs. ethanol + CCl₄; ^## vs. ethanol + CCl₄ + 400.

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