The Potential Mechanism of Zishen Yutai Pills against Threatened Abortion: An Approach Involving Network Pharmacology and Experimental Evidence

<div>ZYP improves the general condition of rats in the RU486-induced TA model. (a) Body changes of rats in each group at 5<sup>th</sup> and 10<sup>th</sup>, respectively. (b) The images of the uterus in all groups of pregnant rats. (c) H&amp;E staining was performed on the uterus to observe histopathologic changes. The red arrow represents histopathologic changes in the uterine section with the embryo. (d, e) Serum levels of E2 and <svg height="8.68572pt" id="M21" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> were detected by ELISA assay <i>n</i> = 6, <span class="nowrap"><svg height="13.532pt" id="M22" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g 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Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: The Potential Mechanism of Zishen Yutai Pills against Threatened Abortion: An Approach Involving Network Pharmacology and Experimental Evidence 

Figure 5 | The Potential Mechanism of Zishen Yutai Pills against Threatened Abortion: An Approach Involving Network Pharmacology and Experimental Evidence 