RAB11A Promotes Cell Malignant Progression and Tumor Formation of Prostate Cancer via Activating FAK/AKT Signaling Pathway

Figure 5

RAB11A promotes migration, invasion, and EMT of prostate cancer cells via activating the FAK/AKT signaling pathway. (a) The migration of PC-3 cells was analyzed by wound healing assay. (b) The invasion of PC-3 cells was analyzed by Transwell assay (scale bar = 50 μm). (c) The protein levels of E-cadherin, N-cadherin, and vimentin were analyzed by western blot analysis. (d) The protein levels of p-FAK/FAK and p-AKT/AKT were analyzed by western blot analysis. The PC-3 cells were pretreated with the FAK inhibitor PF562271 before the transfection with si-RAB11A. ^∗P < 0.05, ^∗∗P < 0.01 vs. si-NC; ^#P < 0.05, ^##P < 0.01 vs. si-RAB11A; &P < 0.05, &&P < 0.01 vs. PF562271.

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