Angelica Yinzi Alleviates Pruritus-Related Atopic Dermatitis through Skin Repair, Antioxidation, and Balancing Peripheral μ- and κ-opioid Receptors

Table 1

Compounds detected and identified in AYZ formula.

No.	RT (min)	formula	MW (Da)	Error (ppm)	MS/MS fragments	Ion Mode	Identification	Resource
1.	0.913	C6H8O7	191.0197	0.14	191.0174, 111.0085, 87.0088	−	Citric acid	Pra
					59.0121
					169.0148
					125.0241
2.	1.358	C7H6O5	169.0142	0.28	97.0298	−	Gallic acid	Pra
					79.0191
					166.0859
					120.0805
3.	1.805	C9H11NO2	166.0862	0.33	103.0538	+	Phenylalanine	Tt, Cx, As, Rg, Ss, Gr
					205.0975			Tt, Cx, As, Ss
					188.0697
4.	3.080	C11H12N2O2	205.0973	−0.71	170.0595	+	Tryptophan
					146.0597
					118.0652			Grr
					209.0465
					165.0553
5.	3.841	C10H10O5	209.0455	0.22	121.0659	−	P-hydroxybenzyl malonate
					93.0349
					59.0149			Pra
					495.1525
					137.0246		Oxypaeoniflorin	Pra
6.	4.237	C23H28O12	495.1512	−0.81	289.0720	−
					245.0812		Catechin
7.	4.239	C15H14O6	289.0718	−0.13	125.0241	−		Ss
					159.0657
					141.0543		2-Propylbutaned
8.	4.465	C7H12O4	159.0663	−0.11	115.0763	−	Ioic acid
					97.0661			As, Cx
					167.0348
					123.0450		Vanillic acid
9.	4.748	C8H8O4	167.0350	−0.11	79.0558	−		Grr
					417.1205
					255.0665		Neoisoliquiritin
10.	4.910	C21H22O9	417.1190	0.25	135.0086	−		Grr
					525.1620
					479.1569		Albiflorin
11.	5.576	C23H28O11	525.1614	−0.07	121.0296	−		Grr
					525.1625
					449.1456		Paeoniflorin
12.	5.942	C23H28O11	525.1614	−0.07	327.1083	−
					121.0294			Pm
					405.1191
					243.0659		Cis-stilbene glycoside	Sr
13.	6.017	C20H22O9	405.1193	−0.48	513.1622	−	Prim-O-glucosylcimifugin
					467.1562
14.	6.221	C22H28O11	513.1613	0.13	305.1022	−
					161.0456		Ferulic acid	As, Cx
					193.0501
					178.0269
15.	6.670	C10H10O4	193.0506	0.17	160.8418	−
					149.0605
					134.0372		Calycosin-7-O-β -d-glucoside	Am
					491.1199		Liquiritin apiosid
					283.0614			Grr
16.	6.749	C22H22O10	491.1196	−0.20	549.1609	−
					417.1173
17.	6.807	C26H30O13	549.1621	−1.34	255.0661	−	Liquiritin
					135.0087			Grr
					417.1184
					255.0659		Trans
18.	6.861	C21H22O9	417.1190	0.25	135.0090	−	Stilbene glycoside	Pm
					405.1199		Cimifugin
					243.0662			Sr
19.	6.965	C20H22O9	405.1190	0.26	307.1181	−
					289.1073
20.	7.179	C16H18O6	307.1176	0.05	259.0599	+	4-O-β-D-glucosyl-5-O-methylvisamminol
					235.0600		Hesperidin	Sr
					497.1659
					451.1622		Mudanpioside I
21.	7.614	C22H28O10	497.1665	−0.10	271.0987	−		Ss, tt
					609.1818
					301.0718		Rosmarinic acid	Pra
22.	7.913	C28H34O15	609.1829	−0.67	525.1610	−
					479.1557
23.	8.192	C23H28O11	525.1618	−0.83	121.0289	−	Senkyunolide I	Ss
					359.0775
					197.0452		Isoliquiritin
24.	8.194	C18H16O8	359.0772	0.11	161.0242	−		Cx, As
					247.0937
					207.1010		Ononin	Grr
25.	8.402	C12H16O4	247.0942	−0.49	417.1179	+
					255.0652		Rabdosiin
26.	8.720	C21H22O9	417.1192	−0.23	135.0079	−		Grr, Am
					475.1236
					267.0666		Glychionide A	Ss
27.	8.787	C22H22O9	475.1246	−0.03	717.1453	−
					519.0932
28.	8.820	C36H30O16	717.1462	−0.13	321.0403	−	Methylvisam minol	Grr
					445.0781
					269.0459
29.	8.895	C21H18O11	445.0774	0.53	113.0245	−	Liquiritigenin	Sr
					291.1226
					243.0647
30.	9.288	C16H18O5	291.1226	0.34	219.0648	+	sec-o-glucosylhamaudol
					191.0696			Grr
					255.0663
					135.0088		5R-3-Heptanone,5-hydroxy-1,7-bis
31.	9.292	C15H12O4	255.0661	0.72	119.0504	−	Benzoylpaeon	Sr
					483.1517		-Iflorin
					437.1463
32.	9.852	C21H26O10	483.1509	−0.21	257.0821	−	Licorice
					179.0554		Saponin G2	Gr
					373.1656
					179.0716		Glycyrrhizic acid
33.	10.634	C21H26O6	373.1661	−1.17		−		Ra
					629.1876
					553.1706		6-Gingerol
34.	10.786	C30H32O12	629.1876	−0.03	121.0293	−	Senkyunolide A	Grr
					837.3923
					351.0584
35.	12.031	C42H62O17	837.3914	−0.21	193.0344	−		Grr
					821.3931
					351.0557
36.	12.314	C42H62O16	821.3964	0.31	193.0348	−		Gr
								Cx
					193.1215
37.	12.724	C17H26O4	294.1825	0.21	175.1110	+
38.	12.978	C12H16O2	193.1221	1.07	147.1163	+
					137.0593

As: Angelica sinensis; Pra: Paeoniae radix alba; Cx: Chuanxiong rhizoma; Rg: Rehmannia glutinosa; Tt: Tribulus terrestris L; Sr: Saposhnikoviae radix; Ss: Schizonepetae spica; Pm: Polygonum multiflorum thunb; Am: Astragalus membranaceus; Grr: Glycyrrhizae radix et rhizoma; and Gr: Ginger root.