<i>Rhinacanthin C</i> Ameliorates Insulin Resistance and Lipid Accumulation in NAFLD Mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC Signaling Pathways

<div>Summary of the study. <i>Rhinacanthin C</i> upregulated the levels of AMPK and SIRT1. High SIRT1 expression reduced MCP-1, TNF-<i>α</i>, and IL-6 activity, which might induce fatty acid oxidation and alleviate inflammatory injury. In addition, RC decreased nucleic SREBP-1c and ACC activity, which might suppress lipogenesis in the liver. Thus, RC ameliorates insulin resistance and lipid accumulation in NAFLD mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC signaling pathways.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 9

Figure 9: <i>Rhinacanthin C</i> Ameliorates Insulin Resistance and Lipid Accumulation in NAFLD Mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC Signaling Pathways 

Figure 9 | Rhinacanthin C Ameliorates Insulin Resistance and Lipid Accumulation in NAFLD Mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC Signaling Pathways 