Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats

Table 3

Effects of oral treatment with Solidago microglossa extract (EESM) and hydrochlorothiazide (HCTZ) on electrocardiographic parameters.

Parameter	Naïve	NC	HCTZ	EESM (14 mg/kg)	EESM (28 mg/kg)	EESM (56 mg/kg)
Segments (ms)
PR	79.80 ± 7.06	79.50 ± 2.44	80.25 ± 2.77	82.29 ± 5.44	81.75 ± 6.40	80.66 ± 4.12
QRS	69.40 ± 2.87	70.13 ± 1.80	71.88 ± 1.80	74.86 ± 8.18	72.25 ± 3.94	71.34 ± 3.01
QT	140.6 ± 10.76	184.6 ± 5.59^a	170.1 ± 6.04^a	179.8 ± 10.66^a	177.8 ± 10.66^a	142.7 ± 7.46^bcde
QTc	271.2 ± 21.53	367.9 ± 14.16^a	329.4 ± 14.15^a	343.6 ± 29.56^a	340.3 ± 27.35^a	290.7 ± 20.77^bcde
Waves (mV)
	0.056 ± 0.009	0.059 ± 0.012	0.055 ± 0.007	0.054 ± 0.007	0.058 ± 0.008	0.056 ± 0.009
Q	−0.010 ± 0.006	−0.014 ± 0.005	−0.015 ± 0.003	−0.011 ± 0.005	−0.010 ± 0.006	−0.012 ± 0.007
R	0.30 ± 0.02	0.39 ± 0.02^a	0.37 ± 0.02^a	0.40 ± 0.02^a	0.41 ± 0.03^a	0.31 ± 0.02^bcde
S	−0.076 ± 0.02	−0.074 ± 0.02	−0.076 ± 0.02	−0.077 ± 0.02	−0.075 ± 0.02	−0.074 ± 0.02

Statistical analyses were performed using one-way ANOVA followed by Tukey’s test. Values are expressed as mean ± SEM (standard error of the mean) of 8 animals per group. ^a when compared to the naïve rats. ^b when compared to the NC group. ^c when compared to the EESM 14 mg/kg. ^d when compared to the EESM 28 mg/kg. ^e when compared to the HCTZ. EESM: hypertensive rats that received three different doses of the Solidago microglossa extract; HCTZ: hypertensive animals that received daily doses of hydrochlorothiazide (25 mg/kg); NC: hypertensive animals that received daily doses of the vehicle; Naïve: normotensive animals that received only the vehicle.