Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats

Table 4

Effects of oral treatment with Solidago microglossa extract (EESM) and hydrochlorothiazide (HCTZ) on blood pressure values.

Parameter	Naïve	NC	HCTZ	EESM (14 mg/kg)	EESM (28 mg/kg)	EESM (56 mg/kg)
SBP (mm·Hg)	114 ± 7.33	154 ± 5.44^a	111 ± 2.89^bcd	155 ± 3.95^a	147 ± 3.45^a	117 ± 7.11^bcd
DBP (mm·Hg)	76.4 ± 4.04	103.3 ± 4.97^a	80.3 ± 3.28^bcd	105.1 ± 3.65^a	99.8 ± 3.43^a	78.4 ± 3.12^bcd
MAP (mm·Hg)	92.2 ± 3.69	122.2 ± 4.01^a	96.5 ± 3.97^bcd	118.1 ± 3.30^a	117.0 ± 4.01^a	90.8 ± 3.55^bcd
HR (bpm)	237 ± 15.3	394 ± 20.72^a	302 ± 17.53^abcd	378 ± 21.66^a	376 ± 23.30^a	297 ± 20.3^abcd

Statistical analyses were performed using one-way ANOVA followed by Tukey’s test. Values are expressed as mean ± SEM (standard error of the mean) of 8 animals per group. ^a when compared to the naïve rats. ^b when compared to the NC group. ^c when compared to the EESM 14 mg/kg. ^d when compared to the EESM 28 mg/kg. EESM: hypertensive rats that received three different doses of the Solidago microglossa extract; HCTZ: hypertensive animals that received daily doses of hydrochlorothiazide (25 mg/kg); NC: hypertensive animals that received daily doses of the vehicle; Naïve: normotensive animals that received only the vehicle. DBP: diastolic blood pressure; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure.