Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats

Table 6

Effects of oral treatment with Solidago microglossa extract (EESM) and hydrochlorothiazide (HCTZ) on mesenteric arterial reactivity.

Parameter	Naïve	NC	HCTZ	EESM (14 mg/kg)	EESM (28 mg/kg)	EESM (56 mg/kg)
Phe (nmol)
1	2.69 ± 0.55	5.01 ± 1.34^a	3.62 ± 1.02^bcd	8.96 ± 3.12^a	8.91 ± 2.76^a	3.41 ± 0.76^bcd
3	3.41 ± 0.68	6.43 ± 1.49^a	4.87 ± 1.13^bcd	13.24 ± 3.28^a	34.52 ± 7.61^a	4.56 ± 0.88^bcd
10	17.36 ± 8.12	65.24 ± 19.10^a	29.04 ± 12.11^bcd	59.65 ± 16.96^a	54.84 ± 50.31^a	22.04 ± 7.11^bcd
30	73.62 ± 9.98	156.61 ± 23.76^a	87.64 ± 9.63^bcd	184.30 ± 20.20^a	146.50 ± 29.38^a	82.33 ± 8.51^bcd
ACh (pmol)
10	−10.81 ± 3.39	−5.84 ± 2.93^a	−13.56 ± 3.64^bcd	−7.73 ± 2.57^a	6.67 ± 1.67^a	−14.21 ± 3.01^bcd
30	−19.78 ± 3.09	−9.03 ± 2.67^a	−17.15 ± 2.98^bcd	−9.00 ± 3.84^a	−10.38 ± 2.01^a	−18.11 ± 2.44^bcd
100	−23.52 ± 4.76	−12.89 ± 3.73^a	−20.78 ± 3.95^bcd	−12.54 ± 3.67^a	−13.51 ± 3.25^a	−23.43 ± 3.74^bcd
300	−35.65 ± 5.46	−12.74 ± 3.76^a	−30.83 ± 6.89^bcd	−10.39 ± 3.82^a	−13.31 ± 4.33^a	−37.77 ± 7.21^bcd
SNP (pmol)
10	−4.11 ± 1.40	−5.25 ± 2.89	−5.53 ± 2.95	−6.20 ± 2.52	−5.57 ± 1.62	−5.11 ± 1.56
30	−6.57 ± 6.73	−6.43 ± 1.62	−7.89 ± 3.62	−7.87 ± 3.32	−8.97 ± 2.79	−6.88 ± 2.51
100	−8.01 ± 2.14	−7.00 ± 2.10	−9.53 ± 3.91	−8.75 ± 3.31	−10.13 ± 2.51	−9.99 ± 2.76
300	−17.64 ± 2.48	−15.99 ± 2.59	−16.34 ± 3.01	−17.56 ± 3.43	−18.12 ± 3.58	−16.34 ± 3.43

Statistical analyses were performed using one-way ANOVA followed by Tukey’s test. Values are expressed as mean ± SEM (standard error of the mean) of 8 animals per group. ^a when compared to the naïve rats. ^b when compared to the NC group. ^c when compared to the EESM 14 mg/kg. ^d when compared to the EESM 28 mg/kg. EESM: hypertensive rats that received three different doses of the Solidago microglossa extract; HCTZ: hypertensive animals that received daily doses of hydrochlorothiazide (25 mg/kg); NC: hypertensive animals that received daily doses of the vehicle; Naïve: normotensive animals that received only the vehicle. ACh: acetylcholine; Phe: phenylephrine; SNP: sodium nitroprusside.