Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats

Table 8

Effects of intraduodenal administration of Solidago microglossa extract (EESM 25 mg/kg) on endothelin and renin-angiotensin system.

Parameter	Baseline blood pressure	Before EESM administration	After EESM administration
Angiotensin I
10 pmoL/kg i.v.
SBP (mm·Hg)	150 0.6 ± 3.22	190.7 ± 10.52^a	197.5 ± 10.21^a
DBP (mm·Hg)	95.2 ± 4.01	129.7 ± 9.24^a	125.1 ± 11.44^a
MAP (mm·Hg)	114.5 ± 4.33	150.7 ± 10.28^a	156.8 ± 9.33^a
Angiotensin II
10 pmoL/kg i.v.
SBP (mm·Hg)	155.9 ± 5.21	220.8 ± 15.32^a	221.7 ± 16.77^a
DBP (mm·Hg)	96.5 ± 4.88	133.5 ± 14.77^a	133.4 ± 15.44^a
MAP (mm·Hg)	118.6 ± 5.24	155.5 ± 13.21^a	157.8 ± 12.77^a
Endothelin
10 pmoL/kg i.v.
SBP (mm·Hg)	149.6 ± 5.11	194.2 ± 8.33^a	142.9 ± 4.21^b
DBP (mm·Hg)	97.8 ± 5.24	120.3 ± 7.21^a	95.1 ± 3.77^b
MAP (mm·Hg)	119.8 ± 4.99	147.5 ± 7.77^a	147.7 ± 9.21^b

Statistical analyses were performed using one-way ANOVA followed by Tukey’s test. Values are expressed as mean ± SEM (standard error of the mean) of 8 animals per group. ^a when compared to baseline. ^b when compared to before EESM administration. DBP: diastolic blood pressure; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure.