Toxicity Profiling and Antihyperuricemic Activity of Goubion: A Polyherbal Formulation

Table 5

Effect of different doses of Goubion on biochemical parameters in female rats.

Groups	Renal profile			Cholesterol profile				Hepatic profile
	Uric acid mg/dL	Creatinine mg/dL	Urea mg/dL	Cholesterol mg/dL	HDL cholesterol mg/dL	LDL cholesterol mg/dL	Triglycerides mg/dL	SGOT IU/L	SGPT IU/L	ALP IU/L
Control	0.92 ± 0.04	0.48 ± 0.01	49.20 ± 0.48	49.30 ± 0.79	16.40 ± 0.24	21.86 ± 0.49	55.47 ± 0.28	25.40 ± 0.24	25.20 ± 0.48	318.00 ± 4.35
15 mg/kg/day	1.00 ± 0.14	0.45 ± 0.01	60.41 ± 3.15	37.51 ± 0.28	5.09 ± 0.36	20.77 ± 0.45	58.23 ± 5.52	24.08 ± 2.75	23.00 ± 1.78	265.00 ± 22.36
30 mg/kg/day	0.94 ± 0.11	0.42 ± 0.00	68.93 ± 0.25	51.91 ± 7.75	9.44 ± 2.54	29.58 ± 1.94	64.42 ± 16.31	19.85 ± 3.90	28.00 ± 0.44	400.00 ± 47.26
60 mg/kg/day	1.40 ± 0.04	0.53 ± 0.01	60.46 ± 1.75	31.96 ± 0.22	14.21 ± 0.23	13.86 ± 0.49	22.28 ± 0.75	37.20 ± 0.64	47.60 ± 1.12	316.80 ± 5.64

¹Results are expressed as mean ± SEM (n = 5). ²One way ANOVA with posthoc Tukey was applied. ³indicates .