Toxicity Profiling and Antihyperuricemic Activity of Goubion: A Polyherbal Formulation

Table 6

Effect of different doses of Goubion on biochemical parameters in male rats.

Groups	Renal profile			Cholesterol profile				Hepatic profile
	Uric acid mg/dL	Creatinine mg/dL	Urea mg/dL	Cholesterol mg/dL	HDL cholesterol mg/dL	LDL cholesterol mg/dL	Triglycerides mg/dL	SGOT IU/L	SGPT IU/L	ALP IU/L
Control	1.84 ± 0.02	0.47 ± 0.01	51.20 ± 0.48	48.85 ± 0.76	18.58 ± 0.60	18.37 ± 0.44	59.50 ± 3.05	24.80 ± 0.48	26.40 ± 0.50	316.00 ± 1.87
15 mg/kg/day	1.72 ± 0.03	0.32 ± 0.02	60.10 ± 4.10	49.31 ± 1.22	9.28 ± 1.61	28.48 ± 0.42	57.75 ± 15.18	23.12 ± 2.70	35.80 ± 2.47	292.40 ± 13.71
30 mg/kg/day	1.76 ± 0.05	0.32 ± 0.03	48.71 ± 4.40	44.32 ± 0.82	14.71 ± 0.96	26.36 ± 0.35	16.27 ± 1.09	23.79 ± 0.54	50.00 ± 2.23	396.20 ± 60.31
60 mg/kg/day	1.06 ± 0.07	0.30 ± 0.05	61.13 ± 2.92	43.91 ± 0.00	12.16 ± 2.84	23.01 ± 3.76	43.17 ± 4.60	24.97 ± 1.63	38.00 ± 0.89	241.80 ± 15.43

¹Results are expressed as mean ± SEM (n = 5). ²One way ANOVA with posthoc Tukey was applied. ³indicates .